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Eleventh International Symposium on
Mass Spectrometry in the Health & Life Sciences:
Molecular & Cellular Proteomics

Program

August: 16 | 17 | 18 | 19 | 20 | 21

Saturday, August 16

Symposium and Mini-Symposium Registration
Foyer, Monterey Room, Hotel Nikko, 222 Mason Street, San Francisco

3:00pm Registration

Sunday, August 17

Symposium and Mini-Symposium Registration
Nikko Ballroom Foyer

7:30am Registration

Mini-Symposium on Methods of Protein Quantitation and Dynamics
Nikko Ballroom

Chair: Daniel Liebler, Vanderbilt University School of Medicine, Nashville , TN, USA

8:30am MS.1 Improving the Robustness and Reproducibility of Mass Spectrometry Based Proteomics
Michael MacCoss, University of Washington, Seattle, WA, USA
9:30 MS.2 SWATH-MS: Principles and Applications to Quantitative Biology
Ruedi Aebersold, ETH Zurich, Zurich, Switzerland
10:10 Coffee break
10:50 MS.3 Measuring cell signaling and pharmacodynamics using immuno-MRM
Jeffrey Whiteaker, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
11:30 MS.4 Improving multiplexing limits of parallel reaction monitoring (PRM) through longer one-dimensional chromatography and use of diverse retention time-normalized spectral libraries
Anatoly Urisman, University of California, San Francisco, California, USA
12:10pm Lunch

Chair: Steven A. Carr, The Broad Institute of MIT and Harvard Cambridge, MA, USA

1:40pm MS.5 Recent Advances in HRAM Quantification: Application to Clinical Assays
Bruno Domon, Centre de Recherche Public de la Santé (CRP-Santé), Strassen, Luxembourg
2:20 MS.6 Expanding Roles of Targeted MS in Biology and Medicine
Hasmik Keshishian, The Broad Institute of MIT and Harvard, Cambridge, MA, USA
3:00 MS.7 Emerging Approaches to Monitoring Chemotherapeutic Response
Arun Wiita, University of California, San Francisco, California, USA
3:40 MS.8 Regulation of Protein Acylation by SIRT3 and SIRT5
Bradford Gibson, Buck Institute for Research on Aging, Novato, CA, USA

Nikko Ballroom Vestibule

4:00pm Symposium Registration

Monterey & Carmel Rooms

4:00pm Symposium Poster Set-up

Golden Gate Room, 25th floor

6:00pm Opening Reception

Monday, August 18

Nikko Ballroom Foyer

7:30am Registration

Symposium: Emerging Challenges in Medicine and Biology
Nikko Ballroom

8:15am Introduction
Ruedi Aebersold, A.L. Burlingame and Steven A. Carr

Chair: Arun Wiita, University of California, San Francisco, CA, USA

8:30am 1.1 Plenary Lecture
Big Data and Human Disease: The New Era
Michael Snyder, Stanford University, Stanford, California, USA

Chair: Daniel Liebler, Vanderbilt University School of Medicine, Nashville , TN, USA

9:30am 1.2 Mass spectrometry based draft of the human proteome
Bernard Kuster, Technical University Munich, Freising, Germany
10:10 Coffee break
10:30 1.3 Network Approaches to Aggregating Variants and Mutations.
Trey Ideker, University of California, San Diego, CA, USA
11:10 1.4 Single Cell Network Analysis in 3D
Bernd Bodenmiller, University of Zurich, Zurich, Switzerland
11:50 1.5 Spatially-resolved proteomic mapping of living cells (with a focus on mitochondria) using engineered peroxidase reporters
Alice Ting, Massachusetts Institute of Technology, Cambridge, MA, USA
12:30pm Lunch

Chair: Bradford Gibson, Buck Institute for Research on Aging, Novato, CA, USA

2:00pm 2.1 Use of Personalized Sequence Databases for Peptide MS/MS Spectrum Matching in the Proteogenomic Analysis of 105 TCGA Breast Tumors
Karl R. Clauser, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
2:40 2.2 Proteogenomic analysis of human breast cancer connects genetic alterations to phosphorylation networks
Philipp Mertins, Broad Institute of MIT and Harvard, Cambridge, MA, USA
3:20 2.3 Proteogenomic Analysis of Human Colon and Rectal Cancer
Daniel Liebler, Vanderbilt University School of Medicine, Nashville , TN, USA

Symposium Poster Session A
Monterey & Carmel Rooms

Co-Chairs: , University of California, San Francisco, California, USA

4:00pm Poster Session A

Tuesday, August 19

Symposium: Methodologies Enabling New Insights into Biology I
Nikko Ballroom

Chair: Steven A. Carr, The Broad Institute of MIT and Harvard, Cambridge, MA, USA

8:30am 3.1 Plenary Lecture
Systems analysis of mitochondrial pathogenesis.
Vamsi Mootha, Harvard Medical School, Boston, MA, USA

Chair: Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ONT, Canada

9:30am 3.2 PTMomics - towards comprehensive quantitative analysis of multiple PTMs from biological material
Martin Larsen, University of Southern Denmark, Odense, Denmark
10:10 Coffee break
10:30 3.3 Epigenetic and metabolic regulation by a family of new lysine acylation pathways
Yingming Zhao, University of Chicago, Chicago, IL, USA
11:10 3.4 Identification and characterization of caspase substrates that regulate axon degeneration in development and disease
Nicholas Hertz, Rockefeller University, New York, NY, USA
11:50 3.5 Proteomics and the functional organization of axons
Matthew Rasband, Baylor College of Medicine,Houston, TX, USA
12:30pm Lunch

Chair: Bernard Kuster, Technical University Munich, Freising, Germany

2:00pm 4.1 High resolution LC coupled with high resolution MS for in-depth proteomics
Yasushi Ishihama, Kyoto University, Kyoto, Japan
2:40 4.2 NeuCode Mouse and One Hour Proteomes
Joshua Coon, University of Wisconsin-Madison, Madison, WI, USA
3:20 4.3 How proteomics big data will transform mass spectrometry data analysis
Nuno Bandeira, University of California, San Diego, CA, USA

Symposium Poster Session B
Monterey & Carmel Rooms

Co-Chairs: , University of California, San Francisco, California, USA

4:00pm Poster Session B

Wednesday, August 20

Symposium: Methodologies Enabling New Insights into Biology II
Nikko Ballroom

Chair: Averil Ma, University of California, San Francisco, California, USA

8:30am 5.1 Resolving sites of protein palmitoylation using quantitative proteomics
Mark Collins, The University of Sheffield, England, UK
9:10 5.2 A novel comprehensive discovery approach for SUMO modified proteins.
Elizabeth Komives, University of California, San Diego, CA, USA
9:50 5.3 NeuCode Mass Spectrometry Unveils New Roles for Ubiquitin Machinery in Metabolic Homeostasis
Josh Baughman, Genentech, Inc., South San Francisco, CA, USA
10:30 Coffee break

Chair: Gerald Hart, Johns Hopkins University School of Medicine, Baltimore, MD, USA

10:50am 5.4 Plenary Lecture
Functional Glycomics - Defining Glycan Recognition by Proteins
Richard Cummings, Emory University, Atlanta, GA, USA
11:50 Lunch

Chair: Ruedi Aebersold, ETH Zurich, Zurich, Switzerland

1:20pm 6.1 Dynamic profiling of the protein life cycle reveals two distinct strategies for controlling differential expression of immune and housekeeping protein levels in response to pathogens
Marko Jovanovic, The Broad Institute of MIT and Harvard, Cambridge, MA, USA
2:00 6.2 High-Throughput Proteomic Mapping of Protein Interaction Networks: Toward a Global View of the Human Interactome
Edward L. Huttlin, Harvard Medical School, Boston, MA, USA

Symposium Poster Session C
Monterey & Carmel Rooms

Co-Chairs: , University of California, San Francisco, California, USA

2:40pm Poster Session C

Conference Dinner
Nikko Ballroom

6:00pm Conference Dinner Reception
Foyer, Nikko Ballroom?
7:00 Conference Dinner
Nikko Ballroom

Thursday, August 21

Symposium: Methodologies Enabling New Insights into Biology III
Nikko Ballroom

Chair: Odile Burlet-Schiltz, Institute of Pharmacology and Structural Biology (IPBS), CNRS, Toulouse, France

8:30am 7.1 Proteomic Advances for Epigenetics Research
Ben Garcia, University of Pennsylvania Medical School, Philadelphia, PA, USA
9:10 7.2 Dissecting the role of the extracellular matrix in cancer progression: a proteomics-based approach
Alexandra Naba, Massachusetts Institute of Technology, Cambridge, MA, USA
9:50 7.3 Signaling interactome dynamics in health and disease
Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ONT, Canada
10:30 Coffee break
11:00 7.4 Structure of RNA polymerase II – Mediator holoenzyme investigated through an integrated mass spectrometry and electron microscopy approach.
Michael Trnka, University of California, San Francisco, CA, USA
11:40 Lunch

Chair: A.L. Burlingame, University of California, San Francisco, California, USA

1:40pm 8.1 Photo-cross-linking and high-resolution mass spectrometry for assignement of RNA-binding sites in RNA-binding proteins
Henning Urlaub, Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany
2:20 8.2 Cellular Immune Response versus Viral Immune Evasion: Lessons from Proteomics
Ileana Cristea, Princeton University, Princeton, NJ, USA
3:00 8.3 Genetic Variability and the Quantitative Proteome
Ruedi Aebersold, ETH Zurich, Zurich, Switzerland

Chair: Ralph A. Bradshaw, University of California, San Francisco, California, USA

3:40pm 8.4 Plenary Lecture
The interplay between protein phosphorylation and protein ubiquitylation in regulating the innate immune system
Sir Philip Cohen, University of Dundee, Scotland, UK

 

4:40pm Closing remarks
5:00 Adjourn

 


last modified Mon Jul 28 10:27:11 2014 PDT