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Twelfth International Symposium on
Mass Spectrometry in the Health & Life Sciences:
Molecular & Cellular Proteomics

Program

2017

August: 19 | 20 | 21 | 22 | 23 | 24

Saturday, August 19

Symposium and Mini-Symposium Registration
Mendocino I Room, Second Floor Foyer, Hotel Nikko, 222 Mason Street, San Francisco

3:00pm Registration

Sunday, August 20

Symposium and Mini-Symposium Registration
Nikko Ballroom Foyer

7:30am Registration

Mini-Symposium on Chemical Proteomics
Nikko Ballroom

Chair: Bernhard Küster, Technical University Munich,Freising, Germany

8:30am MS.1 Thermal proteome profiling for unbiased assessment of protein state and function in live cells.
Mikhail Savitski, European Molecular Biology Laboratory (EMBL)
9:30 MS.2 SILAC in vitro quantitative profiling of colon cancer spheroids treated with combination chemotherapies in a 3D printed fluidic device.
Amanda Hummon, University of Notre Dame
10:10 Coffee break
10:50 MS.3 The target landscape of clinical kinase inhibitors.
Susan Klaeger, The Broad Institute of MIT and Harvard
11:30 MS.4 Towards a comprehensive strategy for target identification of small molecule drug candidates using quantitative chemical proteomics and orthogonal approaches.
Markus Schirle, Novartis Institutes for BioMedical Research
12:10pm Lunch

Chair: Nicholas Hertz, Stanford University, Stanford, CA, USA

1:40pm MS.5 Systems Biology of Oncogenic Signaling.
Pedro R. Cutillas, Barts Cancer Institute, Queen Mary University of London
2:20 MS.6 Target ID: successes and lessons learned.
Monica Schenone, The Broad Institute of MIT and Harvard
3:00 MS.7 Chemical-proteomic strategies to investigate reactive cysteines.
Eranthie Weerapana, Boston College
3:40 MS.8 Broad-spectrum kinase profiling in live cells with lysine-targeted chemoproteomic probes.
Jack Taunton, University of California, San Francisco

Nikko Ballroom Vestibule

4:00pm Symposium Registration

Monterey & Carmel Rooms

4:00pm Symposium Poster Set-up

Golden Gate Room, 25th floor

6:00pm Opening Reception

Monday, August 21

Nikko Ballroom Foyer

7:30am Registration

Symposium: Emerging Challenges in Medicine and Biology
Nikko Ballroom

8:15am Introduction
A.L. Burlingame, Steven A. Carr and Bernhard Küster

Chair: Steven A. Carr, The Broad Institute of MIT and Harvard, Cambridge, MA, USA

8:30am 1.1 Plenary Lecture
Identifying and Targeting Tumor Neoantigens.
Catherine Wu, Harvard Medical School

Chair: Robert Chalkley, University of California, San Francisco, CA, USA

9:30am 1.2 Mapping the Glycoproteome with Activated Ion Electron Transfer Dissociation.
Joshua Coon, University of Wisconsin-Madison
10:10 Coffee break
10:30 1.3 Highly multiplexed and targeted imaging of tissues my mass cytometry.
Bernd Bodenmiller, Institute of Molecular Life Science, University of Zurich
11:10 1.4 Pulsed SILAC and TMT labeling reveals proteoform resolved protein dynamics.
Bernhard Küster, Technical University Munich
11:50 1.5 Evolution, dynamics and genetics of protein post-translational control.
Pedro Beltrao, European Bioinformatics Institute (EMBL-EBI)
12:30pm Lunch

Chair: Joshua Coon, University of Wisconsin-Madison, Madison, WI, USA

2:00pm 2.1 Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS.
Tony Ly, University of Dundee
2:40 2.2 Proteome dynamics.
Matthias Selbach, Max-Delbrück-Center for Molecular Medicine(MDC)
3:20 2.3 Quantitative profiling of highly polymorphic multigene products.
Rob Beynon, Institute of Integrative Biology, University of Liverpool

Symposium Poster Session A
Monterey & Carmel Rooms

Co-Chairs: Juan Oses-Prieto and Jason Maynard, University of California, San Francisco, CA, USA

4:00pm Poster Session A

Tuesday, August 22

Symposium: Methodologies Enabling New Insights into Biology I
Nikko Ballroom

Chair: Steven A. Carr, The Broad Institute of MIT and Harvard, Cambridge, MA, USA

8:30am 3.1 FLASH TALKS

Chair: Donald Kirkpatrick, Genentech, South San Francisco, CA, USA

9:30am 3.2 Quantifying Ubiquitin Signaling for Mitophagy.
Wade Harper, Harvard Medical School
10:10 Coffee break
10:30 3.3 Spatial proteomics and transcriptomics.
Alice Y. Ting, Stanford University
11:10 3.4 High-density proximity interactome mapping at steady-state reveals the subcellular organization of mRNA associated granules and bodies
Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
11:50 3.5 MCP Lecturer
Hybrid mass spectrometry approaches targeting cellular signaling.
Albert J. R. Heck, Utrecht University
12:30pm Lunch
12:30pm Thermo Fisher Lunch
Attendance limited, please RSVP by 8/18/17.

Chair: Albert J.R. Heck, Utrecht University, Utrecht, The Netherlands

2:00pm 4.1 Role of mediator in transcription control.
Philip Robinson, Stanford University Medical School
2:40 4.2 Chemical crosslinking based integrative structural biology of the Mediator complex and higher order transcription complexes.
Michael Trnka, University of California, San Francisco
3:20 4.3 N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis.
Michiel Vermeulen, Radboud University

Symposium Poster Session B
Monterey & Carmel Rooms

Co-Chairs: Robert Chalkley and Giselle Knudsen, University of California, San Francisco, CA, USA

4:00pm Poster Session B

Wednesday, August 23

Symposium: Methodologies Enabling New Insights into Biology II
Nikko Ballroom

Chair: Samuel Myers, The Broad Institute of MIT and Harvard, Cambridge, MA, USA

8:30am 5.1 Using Nanoflow LC-MS/MS to Study Metabolic Changes in Low Grade Astrocytoma.
Thomas A. Neubert, New York University School of Medicine
9:10 5.2 Degradomics analysis reveals a neuron specific death domain containing protein that is a caspase 3 cleavage target required for axon degeneration.
Nicholas Hertz, Stanford University
9:50 5.3 Updates from the NO-Seq Zone: Translatome Proteomics in Nerve Axons.
Michael Fainzilber, The Weizmann Institute of Science
10:30 Coffee break

Chair: Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Mt Sinai Hospital, Toronto, ON, Canada

10:50am 5.4 Plenary Lecture
Proteomics technologies for signaling and clinical applications
Matthias Mann, Max Planck Institute of Biochemistry and Novo Nordisk Foundation Center for Protein Research
11:50 Lunch

Chair: Nicholas Hertz, Stanford University, Stanford, CA, USA

1:20pm 6.1 Revealing nascent proteomics in vivo in signaling pathways and cell differentiation.
Craig Forester, University of California, San Francisco
2:00 6.2 CRISPR/Cas9-APEX-mediated proximity labeling enables discovery of proteins associated with a predefined genomic locus.
Samuel Myers, The Broad Institute of MIT and Harvard
2:40 6.3 Growth Factors, Cell Signaling and the rise of Proteomics
Ralph Bradshaw, University of California, San Diego

Conference Dinner
General’s Residence, Fort Mason

6:00pm Conference Dinner Reception
General’s Residence, Fort Mason, Presidio, San Francisco
7:00 Conference Dinner
General’s Residence, Fort Mason, Presidio, San Francisco

Thursday, August 24

Symposium: Methodologies Enabling New Insights into Biology III
Nikko Ballroom

Chair: Robert Beynon, Institute of Integrative Biology, University of Liverpool, England, United Kingdom

8:30am 7.1 On the hunt for cancer neoantigens: is mass spectrometry the solution?
Josh Elias, Stanford University
9:10 7.2 Improvement of sensitivity and comprehensiveness of proteomic analyses using a novel FAIMS interface.
Pierre Thibault, Universite de Montreal
9:50 7.3 Dynamic proteome organization and host defense during viral infection.
Ileana M. Cristea, Princeton University
10:30 Coffee break
11:00 7.4 Structural Analysis of the 26S Proteasome Complex to Understand its Function and Regulation.
Lan Huang, University of California, Irvine
11:40 Lunch

Chair: Anatoly Urisman, University of California, San Francisco, CA, USA

1:40pm 8.1 Towards a new diagnostic tool for urinary tract infection using LC-MSMS in Data Independent Acquisition mode and bacterial specific spectral libraries.
Florence Roux-Dalvai, Centre de Recherche du CHU de Québec, Centre Hospitalier de l'Université Laval
2:20 8.2 Clinical proteomics of response to anti-cancer treatment reveals metabolic control of treatment resistance.
Tamar Geiger, Sackler Faculty of Medicine, Tel Aviv University
3:00 8.3 Opposing effects of cancer type-specific SPOP mutations on BET protein degradation and sensitivity to BET inhibitors.
Namarata Udeshi, The Broad Institute of MIT and Harvard

Chair: Steven A. Carr, The Broad Institute of MIT and Harvard, Cambridge, MA, USA

3:40pm 8.4 Plenary Lecture
Targeted protein degradation induced by thalidomide analogs
Benjamin Ebert, Harvard Medical School

 

4:40pm Closing remarks
5:00 Adjourn

 


last modified Mon Aug 7 13:26:20 2017 PDT