Jason Maynard

Jason Maynard

Position

Assistant Researcher

Email

jason.maynard@ucsf.edu

Education

Ph.D. Cell Biology 2009 Duke University, Durham, NC
B.S. Molecular Biology 2003 University of Pittsburgh, Pittsburgh, PA

Work History

2015-Present: Assistant Researcher, Department of Pharmaceutical Chemistry, University of California, San Francisco
2013-2015: Postdoctoral Employee, Department of Pharmaceutical Chemistry, University of California, San Francisco
2010-2012: Postdoctoral Fellow, Molecular Carcinogenesis, National Institute of Environmental Health Sciences (NIEHS), Durham, NC

Research Interests

I am interested in development and optimization of strategies for large scale isolation of posttranslational modified proteins, including phosphorylation, O-GlcNAcylation, and ubiquitinylation, from different cell and tissue types. While at Duke University, I was trained in cell and molecular biology while I studied the endoplasmic reticulum chaperone GRP94 and its role in Drosophila development and gut function.

Select Publications

Duerfeldt A, Peterson L, Maynard JC, Ng C, Eletto D, Ostrovsky O, Shinogle H, Moore D, Argon Y, Nicchitta C, Blagg B. Development of a Grp94 inhibitor. J Am Chem Soc. 134(23)9796–804 (2012). [Pubmed]

Maynard, JC, Rankin, HB, Pham, T, Zheng, T, Newgard, CB, Spana, EP, Nicchitta, CV. Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Dev Biol. 339(2) 295–306. (2010) [Pubmed]

Lev A, Dimberu P, Das SR, Maynard JC, Nicchitta CV, Bennink JR, Yewdell JW. Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent. J Immunol. 183(7)4205–10. (2009) [Pubmed]

Tewalt EF, Maynard JC, Walters JJ, Schell AM, Berwin BL, Nicchitta CV, Norbury CC. Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo. Immunology. 125(4) 480–91. (2008) [Pubmed]

Lev A, Takeda K, Zanker D, Maynard JC, Dimberu P, Waffarn E, Gibbs J, Netzer N, Princiotta MF, Neckers L, Picard D, Nicchitta CV, Chen W, Reiter Y, Bennink JR, Yewdell JW. The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation. Immunity. 28(6) 787–98. (2008) [Pubmed]

Chu F, Maynard JC, Chiosis G, Nicchitta CV, Burlingame AL. Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. Protein Sci. 15(6)1260–9. [Pubmed]


National Institute of General Medical Sciences Adelson Medical Research Foundation